Why CNS Drugs are Hard

My favorite drug development blog, In the Pipeline, recently posted on why developing drugs for central nervous system orders is so challenging:

"A recent correspondence on the topic of “Why aren’t there more drugs for the big CNS disorders” got me thinking about the topic. My take, having worked in the field, is that there is still so much unmet need in that area because we just don’t understand what's going on. It’s hard to come up with disease-altering therapies when you don’t really understand a single disease in the whole field..."

Entire post here.